产品货号：
Z35766
中文名称：
NKX2-2抗体
英文名称：
Anti-NKX2-2 Antibody (Clone#20N87)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NKX2-2 Antibody (Clone#20N87) |
| 指标别名 | Homeobox protein Nkx 2.2;NK2 homeobox 2;NKX2 2;NKX2.2;NKX2-2;NKX2B |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | IHC,ICC/IF |
| 基因名称 | NKX2-2 |
| 克隆号 | 20N87 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human NKX2.2 |
| 成分 | Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol,0.5mg/mL BSA. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues,including brain,heart andpancreas.During neural development,Sonic hedgehog (Shh) is known to control cell fate and mitogenesis,which is correlated with Shh dosedependent expression of several genes,including Nkx-2.1,Nkx-2.2 and Nkx-2.9.Specifically,the Nkx-2.2 protein is responsible for directing ventral neuronal patterning in response to graded Shh signaling.In the pancreas,Nkx-2.2 is expressed in α,β and pancreatic polypeptide (PP) cells,but not in δ cells.Nkx-2.2 expression is required for differentiation of pancreatic β cells,which produce Insulin.Homozygous null mutations of the Nkx-2.2 gene in mice lead to severe hyperglycemia and death shortly after birth,which suggests that Nkx-2.2 may be an important therapeutic target for pancreatic diseases,including diabetes and cancer. |
| Uniprot ID | O95096 |
| 基因名全称 | Homeobox protein Nkx-2.2|Homeobox protein NK-2 homolog B |
| 推荐稀释比 | IHC 1:100～500 ICC/IF 1:50～100 |
相关搜索：NKX2-2抗体，NKX2-2单抗，Anti-NKX2-2 Antibody (Clone#20N87)